Captain Jean-Luc Picard | Patrick Stewart | 
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Commander William Thomas Riker | Jonathan Frakes |  |
Lieutenant Commander Data | Brent Spiner |  |
Lieutenant Commander Geordi La Forge | LeVar Burton |  |
Lieutenant Worf | Michael Dorn |  |
Doktor Beverly Crusher (Staffel 1, 3–7) | Gates McFadden |  |
Counselor Deanna Troi | Marina Sirtis |  |
Fähnrich Wesley Robert Crusher(Staffel 1–4) | Wil Wheaton |  |
Lieutenant Natasha Yar (Staffel 1) | Denise Crosby |  |
Doktor Katherine Pulaski (Staffel 2) | Diana Muldaur |  |
Reginald Barclay | Dwight Schultz |  |